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For Everyone Touched By Cancer

Your First Chemotherapy Session: What to Expect and How to Prepare

Written by Dr Shara Cohen on 
5th October, 2025
Last revised by: Cancer Care Parcel
Updated: 3rd December, 2025
Estimated Reading Time: 6 minutes

Starting your first chemotherapy session can feel overwhelming, even if you’ve read every leaflet, spoken at length with your medical team, and packed your chemo bag with care. Walking into the clinic or hospital marks the beginning of a journey you didn’t choose, but one you’re bravely facing.

This guide is here to help you through that first day: from arriving at the clinic to heading home - with tips to help you feel less like a passenger and more like an active participant in your care.

Before and during your session

Arriving at the Clinic: Give Yourself Time

Arriving a little early on your first chemotherapy day can ease stress. Extra time helps you get your bearings, find your department, and check in without feeling rushed. A calm start can set the tone for the day. Consider packing a small bag with your first day of chemo essentials, such as a water bottle, snacks, and a comforting blanket. Bringing a friend or family member along can also provide valuable support and help distract you from any anxieties. Remember, taking care of yourself emotionally and physically can make a significant difference in your experience.

When you arrive, you’ll likely be asked for basic details like your name, date of birth, and insurance or hospital ID. You may also receive a wristband or sticker for identification. These steps may feel routine, but they’re important for safe, efficient care.

If possible, bring a friend or family member for support. Some clinics have visitor restrictions, so check ahead. Even if they can’t stay during your infusion, having someone drop you off, wait nearby, or pick you up can be very reassuring.

Meeting Your Medical Team: Ask Questions

Before chemotherapy begins, you’ll usually meet with a nurse or doctor to review your health and recent test results. They may ask how you’ve been feeling, including any new symptoms. Even small things like a cough, rash, or change in sleep can help them tailor your care. They may also provide you with information on how to prepare for chemotherapy, including dietary recommendations and ways to manage potential side effects. Understanding what to expect during treatment can help alleviate anxiety and ensure you feel more in control. Being proactive in your preparation can significantly enhance your overall experience throughout the chemotherapy process.

Your nurse will explain the plan for the day:

  • The medications you’ll receive
  • How long the infusion will last
  • What to expect during the treatment
  • Any pre-medications you might receive to reduce side effects

Don’t hesitate to ask questions. No question is too small—this is your treatment, and understanding it can help you feel more in control.

Checking Vitals and Blood Tests: Safety First

Before your infusion, a nurse will check your vitals, blood pressure, temperature, heart rate, and possibly your weight. You may also have blood tests to check your white cells, platelets, and other levels. If something’s off, your treatment might be delayed to keep you safe.

The Infusion Process

Once everything is in order, your nurse will insert an IV or access your port. A port is a small device implanted under the skin that allows for easier administration of chemotherapy, especially if you’ll be receiving multiple sessions.

You may also receive pre-medications to help prevent nausea or allergic reactions. These medications can be given orally or through the IV line.

The infusion can last from 30 minutes to several hours, depending on your drugs. Some are given slowly to reduce side effects. You might feel a cold sensation, taste metal, or smell something odd; these are normal, but tell your nurse if anything feels wrong, like itching or trouble breathing.

Staying Comfortable During Chemo Treatment

Many people wonder how to spend their time during a chemotherapy infusion. There’s no right or wrong way to use this time - it’s about what works for you.

Some people enjoy chatting with staff or other patients, while others prefer to focus on books, music, or podcasts. You might also consider bringing a journal to jot down any thoughts or questions you want to remember for later.

Stay comfortable and emotionally grounded

If your clinic allows, try to move around a bit - adjust your position or stretch your legs to prevent stiffness. Some clinics permit patients to walk around with their IV pole; ask your nurse if that’s an option for you.

Eating during treatment is usually fine as long as your stomach tolerates it. Light snacks like crackers, bananas, or rice cakes can help settle your stomach. Drinking water throughout your session can also help your body process the chemotherapy drugs.

Managing Emotions: It’s Okay to Feel Whatever You Feel

Your first session can trigger a range of emotions - anxiety, sadness, relief, or even a sense of accomplishment that you’ve reached this step.

Some people feel tearful as the reality of treatment sets in; others feel calm, focused, or even numb. Every reaction is valid.

If your emotions start to feel overwhelming, talk to your nurse. They are experienced in supporting patients through the emotional aspects of treatment. Even just saying, “I’m feeling really anxious,” can help you feel more grounded.

If you’re alone, it’s perfectly okay to take a moment to yourself. Close your eyes, listen to music, or simply sit quietly. Many clinics understand the need for privacy and will respect your space if you prefer to be left alone.

After the Infusion: Getting Ready to Go Home

Once your infusion ends, your nurse may give you a saline flush to clear the IV line. They’ll remove the IV or disconnect your port and check your vital signs again. They’ll also ensure you’re feeling well enough to go home.

Before you leave, your nurse or doctor will review any medications you should take at home, such as anti-nausea pills or other supportive drugs. They’ll also go over which symptoms need immediate medical attention, like:

  • A fever (typically 38°C / 100.4°F or higher)
  • Chest pain or shortness of breath
  • Severe or persistent vomiting or diarrhoea
  • Unusual bruising, bleeding, or signs of any infection

You’ll also be given contact details for your healthcare team. Don’t hesitate to call if you have any concerns between sessions.

At Home: Recovery Tips

Most people can go home on their own or with a companion after their first chemotherapy session. Fatigue is common, and while some people feel fine initially, side effects like tiredness or nausea may develop later in the day. Plan to rest when you get home, and if possible, have someone stay with you for the first 24 hours just in case you need extra support.

Aftercare and ongoing support

Hydration is crucial - drink plenty of water to help your body process the chemotherapy drugs. Eat a light meal if you’re hungry, and don’t be surprised if your appetite changes. Small, frequent snacks may be easier to manage than one big meal.

Tracking Symptoms: Stay Informed, Stay Empowered

As soon as you get home, start a symptom log or use an app to track how you’re feeling. Write down any side effects - nausea, fatigue, headaches, mood changes - and any questions you want to ask your healthcare team at your next visit.

This record isn’t just for your next appointment – it will help your team tailor your treatment and give you a clearer sense of pattern and progress over time.

Practising Self-Care: Be Kind to Yourself

Allow yourself to rest as much as you need. Chemotherapy is both physically and emotionally demanding. Even small acts of self-care - watching a favourite show, listening to music, journaling, or spending time with a pet can help lift your spirits.

Additionally, reach out for support. Let friends and family help, even with small things like a friend making you a cup of tea or a neighbor picking up your groceries. These small acts of kindness matter.

When to Call for Help

Keep your care team’s contact info handy and know when to reach out. If something doesn’t feel right, it’s always better to check. Call your medical team immediately if you experience:

  • Signs of infection, like chills, body aches, or flu-like symptoms
  • Trouble breathing or chest discomfort
  • Persistent vomiting or diarrhoea that prevents you from eating or drinking
  • Sudden bruising, bleeding, or confusion

Trust your instincts. You know your body best—if something doesn’t feel right, don’t wait. It’s okay to ask for help or reassurance at any time.

Final Thoughts: You’re Not Alone

Your first chemo session is more than just a medical treatment; it’s a brave step forward. No matter how much preparation you have done, it’s normal to feel a mix of emotions.

Take things one step at a time. Remember: you’re not alone. Your medical team, your loved ones, and organisations like Cancer Care Parcel are here to support you at every stage.

Stay informed, stay supported, and most importantly, be kind to yourself!

Edited by: Divsha Bhat

Written by Dr Shara Cohen

With over 30 years of experience in medical research, business, and patient advocacy, Shara combines her scientific expertise with deep empathy to create thoughtful care packages and educational resources that address the emotional and physical challenges of cancer.


Before founding Cancer Care Parcel, Shara built a distinguished career as a biomedical scientist and entrepreneur, publishing extensively and leading successful ventures in life sciences communication and community engagement. Recognised with the British Empire Medal (BEM) for her services to cancer patients and women in STEM, she continues to champion awareness, dignity, and compassion in cancer care—ensuring that no one feels forgotten during or after treatment.

We strongly advise you to talk with a health care professional about specific medical conditions and treatments. 
The information on our site is meant to be helpful and educational but is not a substitute for medical advice.

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